Cryptic crossword clue
Heavyweight boxer typically ends in loss 8

The most common and most likely answer to this crossword clue is the 8 letter word FATALITY

I've seen this crossword clue in The Daily Telegraph
F
A
T
A
L
I
T
Y

Buddy explains!

The straight part
We know that "loss" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loss = fatality.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FATALITY mean?

FATALITY noun
  1. The state proceeding from destiny; invincible necessity, superior to, and independent of, free and rational control.
  2. Tendency to death, destruction or danger, as if by decree of fate.
  3. That which is decreed by fate or which is fatal; a fatal event.
  4. Death.
  5. An accident that causes death.
  6. A person killed.
  7. A move where one character kills another.

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