The most common and most likely answer to this crossword clue is the 8 letter word ELEPHANT
I've seen this crossword clue in The Times
E
L
E
P
H
A
N
T
More clues leading to the result ELEPHANT
- Representing Nepal, the largest living land animal
- From Nepal, the wild animal
- He won’t forget Jumbo?
- Help net a surprisingly large creature
- The panel rudely ignored occupant of room?
- Hannibal’s introduction into European battle, nothing less?
- Reposition the panel, revealing frequently overlooked room feature
- Trumpeter amazing the panel
- & 15 He’s gate-crashed metropolitan hen bash – it’s rather embarrassingly ignored
- Who’ll never forget husband stuffing rubbish into overturned box
Buddy explains!

The straight part
We know that "large creature" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large creature = elephant.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ELEPHANT mean?
ELEPHANT noun- A mammal of the order Proboscidea, having a trunk, and two large ivory tusks jutting from the upper jaw.
- Anything huge and ponderous.
- Used when counting to add length, so that each count takes about one second
- Ivory.
- A large size of paper, measuring 23 by 28 inches, or sometimes 22 by 30, or (double elephant paper) 26 by 40 inches.