Cryptic crossword clue
Herb's most uneasy inside car by day's end 8

The most common and most likely answer to this crossword clue is the 8 letter word COSTMARY

C
O
S
T
M
A
R
Y

Buddy explains!

The straight part
We know that "Herb" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case herb = costmary.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does COSTMARY mean?

COSTMARY noun
  1. An aromatic plant, Tanacetum balsamita, once used to flavour ale (prior to the use of hops)

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