Cryptic crossword clue
   Herculean wife in seven-gated city dropping case 4

The most common and most likely answer to this crossword clue is the 4 letter word HEBE

I've seen this crossword clue in Independent
H
E
B
E


Buddy explains!

The straight part
We know that "Herculean wife" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case herculean wife = hebe.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HEBE mean?

HEBE noun
  1. A Jew.

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