Cryptic crossword clue
He’s overcome by unusual symptom of cold 5

The most common and most likely answer to this crossword clue is the 5 letter word RHEUM

I've seen this crossword clue in The Daily Telegraph
R
H
E
U
M


Buddy explains!

The straight part
We know that "symptom of cold" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case symptom of cold = rheum.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RHEUM mean?

RHEUM noun
  1. Watery or thin discharge of serum or mucus, especially from the eyes or nose, formerly thought to cause disease.
  2. Illness or disease thought to be caused by such secretions; a catarrh, a cold; rheumatism.
  3. Tears.

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