Cryptic crossword clue
High quality of sound after soprano departs

The most common and most likely answer to this crossword clue is the 6 letter word STONED

I've seen this crossword clue in Independent
S
T
O
N
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D


Buddy explains!

The straight part
We know that "High" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case high = stoned.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STONED mean?

STONED verb
  1. To pelt with stones, especially to kill by pelting with stones.
  2. To wall with stones.
  3. To remove a stone from (fruit etc.).
  4. To form a stone during growth, with reference to fruit etc.
  5. To intoxicate, especially with narcotics. (Usually in passive)
  6. To do nothing, to stare blankly into space and not pay attention when relaxing or when bored.
  7. To lap with an abrasive stone to remove surface irregularities.
STONED adjective
  1. Containing stones.
  2. Having had the stones removed.
  3. Drunk; intoxicated by alcohol.
  4. High on drugs, especially cannabis.
  5. Exhilarated, intoxicated by something (such as love) other than drugs or alcohol.

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