The most common and most likely answer to this crossword clue is the 6 letter word STONED
I've seen this crossword clue in Independent
S
T
O
N
E
D
More clues leading to the result STONED
- Completely gone — as are cherries?
- High street name in dictionary
- On a high, as your date might be?
- Under the influence, doctor doesn't
- High Street I deserted
- Mick Jagger perhaps joins daughter on a trip
- High street I avoided, ultimately
- High quality of sound after soprano departs
- Out of it, put to death
- Doesn’t fancy being drunk
Buddy explains!

The straight part
We know that "High" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case high = stoned.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does STONED mean?
STONED verb- To pelt with stones, especially to kill by pelting with stones.
- To wall with stones.
- To remove a stone from (fruit etc.).
- To form a stone during growth, with reference to fruit etc.
- To intoxicate, especially with narcotics. (Usually in passive)
- To do nothing, to stare blankly into space and not pay attention when relaxing or when bored.
- To lap with an abrasive stone to remove surface irregularities.
- Containing stones.
- Having had the stones removed.
- Drunk; intoxicated by alcohol.
- High on drugs, especially cannabis.
- Exhilarated, intoxicated by something (such as love) other than drugs or alcohol.