Cryptic crossword clue
High-quality proofs making one more irritated when including page upside down 6

The most common and most likely answer to this crossword clue is the 6 letter word REPROS

R
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P
R
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S

Buddy explains!

The straight part
We know that "High-quality proofs" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case high-quality proofs = repros.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REPROS mean?

REPROS noun
  1. The proof prepared in offset printing, with all elements positioned on the page.
REPROS noun
  1. The act of reproducing new individuals biologically.
  2. The act of making copies.
  3. A copy of something, as in a piece of art; a duplicate.
REPROS noun
  1. The reproduction, reprinting and copying of graphics, especially using electromechanical or photographic methods

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