Cryptic crossword clue
Highest point of a river – source of Ganges 6

The most common and most likely answer to this crossword clue is the 6 letter word APOGEE

I've seen this crossword clue in Financial Times
A
P
O
G
E
E


Buddy explains!

The straight part
We know that "Highest point" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case highest point = apogee.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does APOGEE mean?

APOGEE noun
  1. The point, in an orbit about the Earth, that is furthest from the Earth: the apoapsis of an Earth orbiter.
  2. (more generally) The point, in an orbit about any planet, that is farthest from the planet: the apoapsis of any satellite.
  3. (possibly obsolete outside astrology) The point, in any trajectory of an object in space, where it is furthest from the Earth.
  4. The highest point.

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