Cryptic crossword clue
Highly exhausted lieutenant, semi-retired, is injected with drug  5

The most common and most likely answer to this crossword clue is the 5 letter word HYPED

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Buddy explains!

The straight part
We know that "is injected with drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case is injected with drug = hyped.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HYPED mean?

HYPED verb
  1. To throw (an opponent) using this technique.
HYPED verb
  1. To promote heavily; to advertise or build up.
HYPED adjective
  1. Having been subject to propaganda and promotion; promoted beyond what is reasonable or appropriate.
  2. Excited.

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