The most common and most likely answer to this crossword clue is the 8 letter word TANGLING
I've seen this crossword clue in The Times
T
A
N
G
L
I
N
G
Buddy explains!
The straight part
We know that "getting into a twist" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case getting into a twist = tangling.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TANGLING mean?
TANGLING verb- To become mixed together or intertwined
- To enter into an argument, conflict, dispute, or fight
- To mix together or intertwine
- To catch and hold; to ensnare.
- A tangled structure.