Cryptic crossword clue
Hold out against dire sister to some extent 6

The most common and most likely answer to this crossword clue is the 6 letter word RESIST

I've seen this crossword clue in The Times
R
E
S
I
S
T


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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RESIST mean?

RESIST noun
  1. A protective coating or covering.
RESIST verb
  1. To attempt to counter the actions or effects of.
  2. To withstand the actions of.
  3. To oppose.
  4. To be distasteful to.

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