Cryptic crossword clue
Hold up inner wear, nice to be undressed — seeking pleasure? 10

The most common and most likely answer to this crossword clue is the 10 letter word HEDONISTIC

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Buddy explains!

The straight part
We know that "seeking pleasure" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case seeking pleasure = hedonistic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HEDONISTIC mean?

HEDONISTIC adjective
  1. Devoted to pleasure; epicurean.

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