Cryptic crossword clue
Holmes to initiate subject of one of his cases 10

The most common and most likely answer to this crossword clue is the 10 letter word BLOODHOUND

I've seen this crossword clue in Financial Times
B
L
O
O
D
H
O
U
N
D

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BLOODHOUND mean?

BLOODHOUND noun
  1. A large scenthound famed for its ability to follow a scent many days old, over vast distances. This dog is often used as a police dog to track missing people, fleeing suspects, or escaped prisoners.
  2. A detective or other person skilled at finding people or clues.
  3. A bloodthirsty person.

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