Cryptic crossword clue
Holy Fathers? Toads! 5

The most common and most likely answer to this crossword clue is the 5 letter word PIPAS

P
I
P
A
S

Buddy explains!

The straight part
We know that "Toads" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case toads = pipas.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PIPAS mean?

PIPAS noun
  1. A pear-shaped plucked lute from China.

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