Cryptic crossword clue
Holy Office is impertinent but no end weird 10

The most common and most likely answer to this crossword clue is the 10 letter word PRIESTHOOD

I've seen this crossword clue in The Times
P
R
I
E
S
T
H
O
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D

Buddy explains!

The straight part
We know that "Holy Office" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case holy office = priesthood.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PRIESTHOOD mean?

PRIESTHOOD noun
  1. The role or office of a priest.
  2. Priests as a group; the clergy.
  3. Authority to act in the name of God.

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