The most common and most likely answer to this crossword clue is the 5 letter word INDUS
I've seen this crossword clue in The Times
I
N
D
U
S
More clues leading to the result INDUS
- Home established finally by American river
- Home with mostly clean running water in Asia
- Try quitting business for an Asian river
- Asian banker’s attempt to quit business
- River, one west of North Dakota, America
- Banker in south of France upset
- Polytheists initially sacrificed their local banker
- Try quitting business that’s banked in Asia
- Try to escape from hard work to find the river
- I make my way from Tibet to Pakistan and try to avoid hard work
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.