Cryptic crossword clue
Homeless girl gets home in Rugby maybe 6

The most common and most likely answer to this crossword clue is the 6 letter word GAMINE

I've seen this crossword clue in The Times
G
A
M
I
N
E

Buddy explains!

The straight part
We know that "Homeless girl" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case homeless girl = gamine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GAMINE mean?

GAMINE noun
  1. A (usually female) street urchin; a homeless girl.
  2. A mischievous, playful, elfish, pert girl or young woman.
GAMINE adjective
  1. (of a girl) Having a boyish, mischievous charm; tomboyish.

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