The most common and most likely answer to this crossword clue is the 6 letter word VACATE
V
A
C
A
T
E
More clues leading to the result VACATE
Buddy explains!

The straight part
We know that "Empty" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case empty = vacate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does VACATE mean?
VACATE verb- To move out of a dwelling, either by choice or by eviction.
- To leave an office or position.
- To have a court judgement set aside; to annul.
- To leave an area, usually as a result of orders from public authorities in the event of a riot or natural disaster.