Cryptic crossword clue
Hopeful lover, being rejected, goes off without you and I 6

The most common and most likely answer to this crossword clue is the 6 letter word SUITOR

I've seen this crossword clue in Independent
S
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Buddy explains!

The straight part
We know that "Hopeful lover" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hopeful lover = suitor.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SUITOR mean?

SUITOR noun
  1. One who pursues someone, especially a woman, for marriage; a wooer; one who courts someone.
  2. A party to a suit or litigation.
  3. One who sues, petitions, solicits, or entreats; a petitioner.
SUITOR verb
  1. To play the suitor; to woo; to make love.

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