Cryptic crossword clue
Hopeless days in Rome, one having left partnership 10

The most common and most likely answer to this crossword clue is the 10 letter word DESPAIRING

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Hopeless" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hopeless = despairing.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DESPAIRING mean?

DESPAIRING verb
  1. To give up as beyond hope or expectation; to despair of.
  2. To cause to despair.
  3. (often with “of”) To be hopeless; to have no hope; to give up all hope or expectation.
DESPAIRING noun
  1. A mood or display of despair.
DESPAIRING adjective
  1. Feeling, expressing, or caused by despair; hopeless.

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