Cryptic crossword clue
Hopeless politician enters No 10, well-advised to dismiss positions 2 and 3 10

The most common and most likely answer to this crossword clue is the 10 letter word IMPOSSIBLE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Hopeless" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hopeless = impossible.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMPOSSIBLE mean?

IMPOSSIBLE noun
  1. An impossibility
IMPOSSIBLE adjective
  1. Not possible; not able to be done or happen.
  2. (of a person) Very difficult to deal with.
  3. Imaginary

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