Cryptic crossword clue
Hormone's over — one allowed to shrink 50% 9

The most common and most likely answer to this crossword clue is the 9 letter word ENDOCRINE

E
N
D
O
C
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I
N
E

Buddy explains!

The straight part
We know that "Hormone" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hormone = endocrine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENDOCRINE mean?

ENDOCRINE noun
  1. The secretion of an endocrine gland.
  2. An endocrine gland.
ENDOCRINE adjective
  1. Producing internal secretions that are transported around the body by the bloodstream.
  2. Pertaining to the endocrine glands or their secretions.

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