Cryptic crossword clue
Horse, lion with it 6

The most common and most likely answer to this crossword clue is the 6 letter word HEROIN

I've seen this crossword clue in Independent
H
E
R
O
I
N

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HEROIN mean?

HEROIN noun
  1. A powerful and addictive drug derived from opium producing intense euphoria classed as an illegal narcotic in most of the world.

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