Cryptic crossword clue
Hospital department I trust without reservation 8

The most common and most likely answer to this crossword clue is the 8 letter word ENTIRELY

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "without reservation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case without reservation = entirely.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENTIRELY mean?

ENTIRELY adverb
  1. To the full or entire extent.
  2. To the exclusion of others.

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