Cryptic crossword clue
Host of lice’s heading into cabin, not entirely put out 8

The most common and most likely answer to this crossword clue is the 8 letter word PUBLICAN

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Buddy explains!

The straight part
We know that "Host" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case host = publican.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PUBLICAN mean?

PUBLICAN noun
  1. The landlord of a public house.
  2. A tax collector in Ancient Rome.

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