Cryptic crossword clue
Hot-headed in prison, many seethe and come to grief 5,3,4

The most common and most likely answer to this crossword clue is the 5 plus 3 plus 4 letter word CRASH AND BURN

C
R
A
S
H
A
N
D
B
U
R
N

Buddy explains!

The straight part
We know that "come to grief" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case come to grief = crash and burn.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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