The most common and most likely answer to this crossword clue is the 4 plus 6 letter word LAST RESORT
I've seen this crossword clue in Financial Times
L
A
S
T
R
E
S
O
R
T
More clues leading to the result LAST RESORT
- Only remaining chance to take seaside town
- Hopelessly lost, tears consuming gambler finally — one more throw of the dice?
- One way to get salt when all else fails
- When all else fails, option Carry On Cleethorpes?
- The French way to holiday spot is only course available
- Ultimate expedient – suggesting salt?
- Hotel at Land’s End? One must try this in dire straits
- When all else fails, make do with this salt possibly?
- Desperate solution that lies at the end of the package tour?
- No choice for this holiday destination?
Buddy explains!

The straight part
We know that "One must try this in dire straits" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one must try this in dire straits = last resort.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.