The most common and most likely answer to this crossword clue is the 5 letter word URINE
I've seen this crossword clue in The Guardian
U
R
I
N
E
More clues leading to the result URINE
- Wee statuette? Fig leaves!
- No. 1 statuette, figless?
- Uranium and hydrogen extracted from river water
- Hour in Eagle drinking the amber liquid?
- Water from river surrounding home
- Wee one blocks vessel close to shore
- Water found in solver’s trendy report
- Vessel containing one last bit of pale amber liquid
- Liquid waste, you heard, hard to be extracted from river
Buddy explains!

The straight part
We know that "the amber liquid" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the amber liquid = urine.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does URINE mean?
URINE noun- Liquid waste consisting of water, salts and urea, which is made in the kidneys, stored in the bladder, then released through the urethra.
- To urinate.