Cryptic crossword clue
How disease develops? Way is shown by old book 12

The most common and most likely answer to this crossword clue is the 12 letter word PATHOGENESIS

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "How disease develops?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case how disease develops? = pathogenesis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PATHOGENESIS mean?

PATHOGENESIS noun
  1. The origin and development of a disease.
  2. The mechanism whereby something causes a disease.

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