Cryptic crossword clue
How much of the main substance is present? It’s madness to include lithium 8

The most common and most likely answer to this crossword clue is the 8 letter word SALINITY

I've seen this crossword clue in The Guardian
S
A
L
I
N
I
T
Y

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does SALINITY mean?

SALINITY noun
  1. The quality of being saline.
  2. The concentration of salt in a solution.

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