Cryptic crossword clue
I am left with euphoria ultimately — it’s nice when one’s lost weight 10

The most common and most likely answer to this crossword clue is the 10 letter word IMPORTANCE

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "weight" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case weight = importance.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMPORTANCE mean?

IMPORTANCE noun
  1. The quality or condition of being important or worthy of note.
  2. Significance or prominence.
  3. Personal status or standing.
  4. Something of importance.

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