The most common and most likely answer to this crossword clue is the 3 plus 3 plus 5 plus 2 plus 2 letter word ITS ALL GREEK TO ME
I've seen this crossword clue in The Guardian
I
T
S
A
L
L
G
R
E
E
K
T
O
M
E
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.