The most common and most likely answer to this crossword clue is the 4 plus 6 plus 2 letter word IT’S BEYOND ME
I've seen this crossword clue in The Guardian
I
T
â
€
™
S
B
E
Y
O
N
D
M
E
Buddy explains!
The straight part
We know that "I don’t know" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case i don’t know = it’s beyond me.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.