Cryptic crossword clue
I grant this eye problem could be irritating — and is! 6

The most common and most likely answer to this crossword clue is the 6 letter word IRITIS

I
R
I
T
I
S


Buddy explains!

The straight part
We know that "this eye problem could be irritating" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case this eye problem could be irritating = iritis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IRITIS mean?

IRITIS noun
  1. An inflammation of the iris.

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