The most common and most likely answer to this crossword clue is the 8 letter word IGNORANT
I've seen this crossword clue in Independent
I
G
N
O
R
A
N
T
More clues leading to the result IGNORANT
- Blind soldier in retreat, and not another soldier?
- Stupid sign or antique hoarding
- Not knowing inn argot, confused
- Ringo roused worker maybe in the dark
- I allow clothes back on in the dark
- Groan nit needs to change, being thus?
- Confusing argon with tin is uneducated
- Topless Italian male worker is lacking in awareness
- Endlessly going off on tirade is not clever
- I admit describing refusal as rude
Buddy explains!
The straight part
We know that "not affected by knowledge" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not affected by knowledge = ignorant.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does IGNORANT mean?
IGNORANT noun- One who is ignorant.
- Unknowledgeable or uneducated; characterized by ignorance.
- Not knowing (a fact or facts), unaware (of something).
- Ill-mannered, crude.
- Unknown; undiscovered
- Resulting from ignorance; foolish; silly.