Cryptic crossword clue
I leave after receiving new tirade not affected by knowledge 8

The most common and most likely answer to this crossword clue is the 8 letter word IGNORANT

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "not affected by knowledge" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not affected by knowledge = ignorant.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IGNORANT mean?

IGNORANT noun
  1. One who is ignorant.
IGNORANT adjective
  1. Unknowledgeable or uneducated; characterized by ignorance.
  2. Not knowing (a fact or facts), unaware (of something).
  3. Ill-mannered, crude.
  4. Unknown; undiscovered
  5. Resulting from ignorance; foolish; silly.

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