Cryptic crossword clue
I left flat for ecstasy and inhaled a milder drug 5

The most common and most likely answer to this crossword clue is the 5 letter word VAPED

I've seen this crossword clue in Independent
V
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Buddy explains!

The straight part
We know that "inhaled a milder drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case inhaled a milder drug = vaped.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VAPED mean?

VAPED verb
  1. To inhale the vapor produced by a non-combustible cigarette, most commonly an electronic cigarette.

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