Cryptic crossword clue
I lose mac, awkward thing to wear 8

The most common and most likely answer to this crossword clue is the 8 letter word CAMISOLE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "thing to wear" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case thing to wear = camisole.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CAMISOLE mean?

CAMISOLE noun
  1. A short, sleeveless undergarment worn by women underneath a blouse, or as a form of short négligée.
  2. A straitjacket.
  3. A light jacket with sleeves.

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