The most common and most likely answer to this crossword clue is the 2 plus 3 letter word IN ONE
I've seen this crossword clue in The Times
I
N
O
N
E
More clues leading to the result IN ONE
- I love not being separated
- Primarily, intelligence and love combined
- We note minions relaxed outside working hours
- How drink might be downed at home by individual
- At first go home — carried off, we hear
- Pub importing old ale ultimately as a unit
- Nobody getting behind Independent as an entity?
- United’s low-scoring home win?
- … Io and zero combined
- Combined in vain on expedition
Buddy explains!

The straight part
We know that "not being separated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not being separated = in one.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.