The most common and most likely answer to this crossword clue is the 5 letter word INDUS
I've seen this crossword clue in Independent
I
N
D
U
S
More clues leading to the result INDUS
- Home established finally by American river
- Home with mostly clean running water in Asia
- Try quitting business for an Asian river
- Asian banker’s attempt to quit business
- River, one west of North Dakota, America
- Banker in south of France upset
- Polytheists initially sacrificed their local banker
- Try quitting business that’s banked in Asia
- Try to escape from hard work to find the river
- I make my way from Tibet to Pakistan and try to avoid hard work
Buddy explains!

The straight part
We know that "I make my way from Tibet to Pakistan" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case i make my way from tibet to pakistan = indus.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.