Cryptic crossword clue
I may be drowsiest but not with drugs 8

The most common and most likely answer to this crossword clue is the 8 letter word STEROIDS

I've seen this crossword clue in The Times
S
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Buddy explains!

The straight part
We know that "drugs" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drugs = steroids.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STEROIDS mean?

STEROIDS noun
  1. A class of organic compounds having a structure of 17 carbon atoms arranged in four rings; they are lipids, and occur naturally as sterols, bile acids, adrenal and sex hormones, and some vitamins; many drugs are synthetic steroids.
  2. Any anabolic hormone used to promote muscle growth.
  3. Any chemical compound used to enhance athletic performance.

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