The most common and most likely answer to this crossword clue is the 6 letter word SHRIEK
I've seen this crossword clue in The Daily Telegraph
S
H
R
I
E
K
More clues leading to the result SHRIEK
- Loud yell from hikers in trouble
- Scream from one being eaten by green ogre?
- I must be in comedy film, a scream
- Sound of alarm disturbed hikers
- Grabbed by ogre, I scream
- Cry of one eaten by ogre
- Slow hiker startled literary bird
- This sound pierces!
- Shout out Indian honorific before English king
- One might pierce your ear?
Buddy explains!

The straight part
We know that "a scream" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a scream = shriek.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SHRIEK mean?
SHRIEK noun- A sharp, shrill outcry or scream; a shrill wild cry such as is caused by sudden or extreme terror, pain, or the like.
- An exclamation mark.
- To utter a loud, sharp, shrill sound or cry, as do some birds and beasts; to scream, as in a sudden fright, in horror or anguish.
- To utter sharply and shrilly; to utter in or with a shriek or shrieks.