Cryptic crossword clue
I picked up that man 5

The most common and most likely answer to this crossword clue is the 5 letter word ROGER

I've seen this crossword clue in The Guardian
R
O
G
E
R


Buddy explains!

The straight part
We know that "I picked up that/man" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case i picked up that/man = roger.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ROGER mean?

ROGER interjection
  1. (radio telecommunications) Received (used in radio communications to acknowledge that a message has been received and understood)
ROGER verb
  1. Of a man, to have sexual intercourse with (someone), especially in a rough manner.
  2. To have sexual intercourse.

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