Cryptic crossword clue
I quit Sion in agitation, leading to enquiry 11

The most common and most likely answer to this crossword clue is the 11 letter word INQUISITION

I
N
Q
U
I
S
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N

Buddy explains!

The straight part
We know that "enquiry" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case enquiry = inquisition.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INQUISITION mean?

INQUISITION noun
  1. An investigation or inquiry into the truth of some matter
  2. An inquest
  3. A questioning
  4. The finding of a jury, especially such a finding under a writ of inquiry.
INQUISITION verb
  1. To make inquisition concerning; to inquire into.

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