Cryptic crossword clue
I regret in the morning having knocked back something spicy 6

The most common and most likely answer to this crossword clue is the 6 letter word MASALA

I've seen this crossword clue in The Guardian
M
A
S
A
L
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Buddy explains!

The straight part
We know that "something spicy/something spicy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case something spicy/something spicy = masala.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MASALA mean?

MASALA noun
  1. Any of many blends of spices used in Indian cuisine, most often containing cardamom, coriander, mace together with pepper, nutmeg, fennel seeds, jeera etc.

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