Cryptic crossword clue
I sit with toes twisted – that produces a sort of pain 8

The most common and most likely answer to this crossword clue is the 8 letter word OSTEITIS

I've seen this crossword clue in Financial Times
O
S
T
E
I
T
I
S

Buddy explains!

The straight part
We know that "sort of pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sort of pain = osteitis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OSTEITIS mean?

OSTEITIS noun
  1. Inflammation of bone

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