The most common and most likely answer to this crossword clue is the 13 letter word PERCUSSIONIST
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More clues leading to the result PERCUSSIONIST
Buddy explains!

The straight part
We know that "he’s a big hitter" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case he’s a big hitter = percussionist.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PERCUSSIONIST mean?
PERCUSSIONIST noun- A trained musician who plays percussion instruments, as opposed to a drummer who lacks formal training.