Cryptic crossword clue
If prime suffers and concretion follows, this can cause termination 12

The most common and most likely answer to this crossword clue is the 12 letter word MIFEPRISTONE

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Buddy explains!

The straight part
We know that "this can cause termination" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case this can cause termination = mifepristone.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MIFEPRISTONE mean?

MIFEPRISTONE noun
  1. (steroid drug) A steroid pharmaceutical used to induce abortion, or as an emergency contraceptive.

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