The most common and most likely answer to this crossword clue is the 6 letter word REGION
I've seen this crossword clue in The Guardian
R
E
G
I
O
N
More clues leading to the result REGION
- African river rises, engulfing centre of exposed area
- Ignore troubled area
- Area with system of belief that’s left one unable to participate
- Ignore dodgy neighbourhood
- Ignore changes, in part
- Country to the west in which to discover old tract
- Ignore broadcast in this area
- Northerly river abroad circling old area
- Ignore foggy district
- Ignore developed area
Buddy explains!

The straight part
We know that "area" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case area = region.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does REGION mean?
REGION noun- Any considerable and connected part of a space or surface; specifically, a tract of land or sea of considerable but indefinite extent; a country; a district; in a broad sense, a place without special reference to location or extent but viewed as an entity for geographical, social or cultural reasons.
- An administrative subdivision of a city, a territory, a country.
- The inhabitants of a region or district of a country.
- A place in or a part of the body in any way indicated.
- Place; rank; station; dignity.
- The space from the earth's surface out to the orbit of the moon: properly called the elemental region.