Cryptic crossword clue
Ill at ease, a graduate approaching cast

The most common and most likely answer to this crossword clue is the 7 letter word ABASHED

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Buddy explains!

The straight part
We know that "Ill at ease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ill at ease = abashed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ABASHED mean?

ABASHED verb
  1. To make ashamed; to embarrass; to destroy the self-possession of, as by exciting suddenly a consciousness of guilt, mistake, or inferiority; to disconcert; to discomfit.
  2. To lose self-possession; to become ashamed.
ABASHED adjective
  1. Embarrassed, disconcerted, or ashamed.

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