Cryptic crossword clue
I’m not sure article changing sides in Italian is particularly helpful 12

The most common and most likely answer to this crossword clue is the 12 letter word HUMANITARIAN

I've seen this crossword clue in Financial Times
H
U
M
A
N
I
T
A
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I
A
N

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The straight part
We know that "particularly helpful" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case particularly helpful = humanitarian.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

HUMANITARIAN noun
  1. A scholar of one of the subjects in the humanities.
  2. A person who believes in the philosophy of humanism.
  3. In the Renaissance, a scholar of Greek and Roman classics.
HUMANITARIAN adjective
  1. Relating to humanism or the humanities.
  2. Of a typeface: resembling classical handwritten monumental Roman letters rather than the 19th-century grotesque typefaces.
HUMANITARIAN noun
  1. A person concerned with people's welfare; a do-gooder or philanthropist.
  2. One who believes that Jesus Christ is fully human and not divine.
HUMANITARIAN adjective
  1. Concerned with people's welfare, and the alleviation of suffering; compassionate, humane.
  2. Of or pertaining to the belief that Jesus Christ is fully human and not divine.

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